Understanding and Predicting Breast Cancer Events After Treatment (UPBEAT)

Tarah Ballinger, MD

Primary Investigator

Overview

This study is being done to see if patients receiving chemotherapy for breast cancer affects the heart, the ability to exercise and fatigue when compared to patients who do not have cancer.

Eligibility

You may be eligible for this study if you meet the following criteria:

Conditions:
Breast Cancer,Healthy
Age: Between 18 Years - 100 Years
Gender: Female

Inclusion Criteria

Inclusion Criteria for Women with Stage I - III Breast Cancer:

-Stage I-III female breast cancer (including inflammatory and newly diagnosed or locally recurrent breast cancer) but not metastatic breast cancer being treated with curative intent

-Scheduled to receive chemotherapy

- Able to hold breath for 10 seconds

- Able to walk at least 2 blocks without chest pain, dyspnea, shortness of breath or fainting

- Able to exercise on a treadmill or stationary cycle

- Participants in other ongoing clinical trials are eligible for this study

Inclusion Criteria for Women Free of Cancer for Comparison:

- Healthy female without known coronary artery disease

- Able to hold breath 10 seconds

- Able to walk at least 2 blocks without chest pain, dyspnea, shortness of breath or fainting

- Able to exercise on a treadmill or stationary cycle

- No hx. of cancer

- Never received chemotherapy, radiation therapy, immunotherapy, or had breast surgery

Exclusion Criteria

Exclusion Criteria for Women with Stage I-III Breast Cancer:

- Those with ferromagnetic cerebral aneurysm clips or other intracranial metal; pacemakers, defibrillators, functioning neurostimulator devices or other implanted non-compatible MRI devices

- Symptomatic claustrophobia

- At the beginning of the study, pregnant women and women who are breast-feeding will not be enrolled.

- Severe pulmonary hypertension

- Within the past 6 months:

-- Acute pulmonary embolus

-- Deep vein thrombosis

- Within the past month:

-- Heart attack

-- Unstable or stable angina (cardiac chest pain)

-- Left main coronary artery disease

-- Symptomatic heart failure

-- Uncontrolled hypertension (SBP > 180 mm Hg or DBP > 100mm Hg)

-- Severe valvular heart disease

-- Uncontrolled metabolic disease (diabetes with fasting BS >300 mg/dl, thyrotoxicosis, myxedema)

-- Aortic aneurism (>45 mm diameter) or aortic dissection

-- Uncontrolled slow or fast heart rhythm causing symptoms or hemodynamic compromise

-- Hypertrophic obstructive cardiomyopathy

Exclusion Criteria for Women Free of Cancer for Comparison:

- Inflammatory conditions such as lupus or inflammatory bowel disease

- Overt coronary artery disease or heart failure