MRI Determination of Femoral Neck Cortical Porosity in Chronic Kidney Disease Metabolic Bone Disease (CKD-MBD)

Study Overview

The purpose of this study is to help physicians predict bone fractures in patients with chronic kidney disease (CKD). Patients with kidney failure have an increased risk of hip fractures. Unfortunately, the bone density scans normally used in osteoporosis do not predict these fractures very well. However, new Magnetic Resonance Imaging (MRI) methods have been developed that help identify the amount of water in bone. Bone has two main types of water: (1) water that is attached to the bone itself and (2) water that sits in the normal tiny holes inside the bone. This is important because patients with chronic kidney disease often have large pores (or holes) in their bones that get filled with more of the second type of bone water. Using these MRI methods, a ratio has been developed to estimate how much water is sitting in holes compared to how much water is attached to the bone. This ratio is called the porosity index.

  • IRB Number: 1903118532
  • Research Study Identifier: TX10560
  • Principal Investigator: Paul Niziolek

Recruitment Status


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