MRI Determination of Femoral Neck Cortical Porosity in Chronic Kidney Disease Metabolic Bone Disease (CKD-MBD)

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Chronic Kidney Disease
  • Age: Between 21 - 50 Years
  • Gender: Male or Female

Inclusion Criteria: 

Chronic Kidney Disease Subjects:
Men and women aged 21-50 years old of any ethnicity.
Severe chronic kidney disease (CKD) defined as stage 4 CKD (eGFR 15-29 ml/min), based on one of the last two measures done in the kidney clinic in the past year
Parathyroid hormone (PTH) values greater than 70 pg/mL, which will be determined by one of the last two laboratory data obtained in the past year.
Agrees to participate in the FIT study (IRB # 1707550885).

Healthy Controls:
Men and women matched by age (within 10 years), ethnicity, diabetes mellitus status (present or absent), and BMI (within 5 points).
No diagnosis or evidence of CKD.
Agrees to participate in the FIT study (IRB # 1707550885).

Healthy Subjects for MRI protocol development only (up to 4):
Men and women aged 21-50 years old of any ethnicity.

Exclusion Criteria: 

Chronic Kidney Disease Subjects:
Treatment with chronic corticosteroids of more than 5 mg/day.
Treatment with calcitriol 
Pregnancy.
MRI contraindication.
Subject does not agree to participate in the FIT core study.

Healthy Controls:
Treatment with chronic corticosteroids of more than 5 mg/day.
Pregnancy.
MRI contraindication.
Subject does not agree to participate in the FIT core study.

Healthy Subjects for MRI protocol development only (up to 4):
Contraindication to MRI

Recruitment Status

Open

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