Insights into the Lid Margin: Characterization of Membrane Associated Mucins in Ocular Surface Disease

A
ANNA TICHENOR

Primary Investigator

Overview

Dry eye disease affects millions of people worldwide and due to an incomplete understanding of the pathogenesis of the disease, it is widely underdiagnosed and undermanaged by clinicians. Understanding the contribution of the proteins involved in maintaining boundary lubrication between the ocular surface and eyelids, specifically mucins, may lead to better understanding of disease and potentially to earlier diagnosis of dry eye. The aim of this project is to investigate mucins on the ocular surface and examine differences in people with and without dry eye disease.

Eligibility

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    Dry Eyes
  • Age: Between 18 Years - 100 Years
  • Gender: All

Inclusion Criteria: 
All subjects must be:
oAble to understand and sign an informed consent and HIPAA privacy document.
o18 years of age or older.
oAble and willing to follow protocol instructions.
Subjects will be telephone screened to determine if the subject falls into either Group 1: Dry Eye or Group 2: Normal, depending on the type of subjects still needed to meet enrollment goals.
Group 1 Dry Eye Disease Inclusion:
OSDI score > 33 (administered via telephone screener)
Group 2 Normal Inclusion:
OSDI score < 10 (administered via telephone screener)
All subjects that meet the inclusion/exclusion criteria and consent to participating in the study will be enrolled. 
Data obtained will then be segregated based on clinical findings for later analysis.
 
Exclusion Criteria: 
1.     Under the age of 18
2.Current contact lens wearer (any wear of contact lenses in the past 3 months)
3.Use of any of the following ophthalmic medication within 30 days: antibiotics, anti-fungal, anti-allergy, anti-inflammatory, anti-glaucoma, lifitegrast, restasis
4.Use of artificial tears within 2 days of study visit
5.Active ocular infection or acute allergic conjunctivitis
6.Transmissible or contagious disease such as HIV, TB, measles, meningitis, etc.
7.Significant conjunctival scarring, obvious meibomian gland dysfunction, or other serious ocular condition
8.History of ocular surgery in the past 12 months
9.Participation in a clinical trial involving a drug or device in the past 30 days
 
10.Pregnant or nursing by self-report

Updated on 14 Mar 2023. Study ID: 1908362633

Interested in the study?

Select a study center that’s convenient for you, and get in touch with the study team.

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