Profiling of the Gut Microbiome in Overweight Youth with T1D and Associations with Biomarkers of b-cell Stress and Death.
Aim 1 of the study is to profile the gut microbiome in youths with type 1 diabetes according to their body mass index. The central hypothesis is that the gut microbiome will be altered in obese vs. lean youths with T1D (and when compared to healthy non-diabetic lean and obese youths) and that this could be related to differences in β-cell stress/death. Type 1 diabetes (T1D) is an autoimmune disease characterized by progressive β-cell loss with eventual dependence on exogenous insulin. Our long-term goal is to understand the role of the gut microbiome in the development of T1D in obese and lean individuals, which would ultimately lead to a more targeted therapeutic approaches in those individuals.
Aim 2 is to determine if differences in the gut microbiome profile are associated with differences in measures of β-cell stress/death.
- IRB Number: 1908640459
- Research Study Identifier: TX10578
- Principal Investigator: Heba Ismail
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