An Open-Label Randomized Phase II Study of Combining Osimertinib with and without Ramucirumab in TKI-naïve EGFR-mutant Locally Advanced or Metastatic NSCLC

N
Nasser Hanna, MD

Primary Investigator

Overview

A phase II study for locally advanced or metastatic non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) gene mutation, will test osimertinib with or without ramucirumab. Researchers hope to determine whether combining these drugs is better at controlling this type of cancer than osimertinib alone. To qualify, participants must be adults 18 or older and have locally advanced or metastatic NSCLC with EGFR.

Description

A phase II study for locally advanced or metastatic non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) gene mutation, will test osimertinib with or without ramucirumab. Researchers hope to determine whether combining these drugs is better at controlling this type of cancer than osimertinib alone. To qualify, participants must be adults 18 or older and have locally advanced or metastatic NSCLC with EGFR.

Eligibility

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    non-squamous, non-small cell lung cancer
  • Age: Between 18 Years - 100 Years
  • Gender: All

Inclusion Criteria

 

Written informed consent and HIPAA authorization for release of personal health information prior to registration.

Age ≥ 18 years at the time of consent.

Histologically or cytologically confirmed non-squamous, non-small cell lung cancer.

Locally advanced or metastatic disease, not amenable to curative surgery or radiotherapy.

Ability to take pills by mouth.

Previous treatment with cytotoxic chemotherapy or immunotherapy is allowed.


Exclusion Criteria


Previous treatment with any EGFR TKIs, including erlotinib, gefitinib, afatinib, avitinib, dacomitinib, rociletinib, or osimertinib.
 
Previous treatment with any anti-VEGF medications, including vandetinib, nintedanib, bevacizumab, or ramucirumab.

Refractory nausea and vomiting, chronic gastrointestinal diseases, inability to swallow the formulated product or previous significant bowel resection that would preclude adequate absorption of osimertinib.

Patients with uncharacterized eye disorders.

Males and females of reproductive potential who are not using and effective method of birth control and females who are pregnant or breastfeeding or have a positive (urine or serum) pregnancy test prior to study entry.

Have undergone major surgery within 28 days prior to first dose of protocol therapy, or minor surgery/subcutaneous venous access device placement within 7 days prior to the first dose of protocol therapy. The patient has elective or planned major surgery to be performed during the course of the clinical trial

Updated on 31 Mar 2023. Study ID: 1908483160

Interested in the study?

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