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A Phase II Trial of Chemotherapy plus Pembrolizumab in patients with advanced NSCLC previously treated with PD-1 or PD-L1 Inhibitor

Study Overview

This is a single-arm phase II study of continuation immunotherapy with pembrolizumab following initial benefit with a PD-1 or PD-L1 inhibitor.

Study Description

The purpose of this study is to assess whether continuation of pembrolizumab in combination with next-line chemotherapy will prolong progression free survival by RECIST 1.1 criteria in patients who previously benefitted from a PD-1/PD-L1 inhibitor but now have progressive disease as compared to historical controls.

Additional Information

Participants will not be paid for their participation.


  • IRB Number: 1701894485 (BTCRCLUN15-029)
  • Research Study Identifier: TX7499
  • Principal Investigator: Greg Durm, MD

Recruitment Status

Open

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