Methods to Identify and Treat Severe Asthma Patients: Airway pH Phenotyping

Study Overview

Airway pH in airway health and disease

Not all people with asthma respond well to traditional treatments. This could be because of acid levels in a person’s airway. Acid in the airway inhibits the body’s response to infection and increases inflammation. If medical professionals can easily measure patients’ pH, they could better identify an appropriate, even personalized, treatment.
It has been shown that acid in the airway affects the body’s response to infection, increases inflammation and affects how well some common medications work.  Right now, airway pH can be measured most accurately by a bronchoscopy, a procedure where a camera is inserted into the airway.  Our goal is to develop an easier, non-invasive way of measuring pH that can be done in a doctor’s office.  This will allow us to use targeted, personalized medicine to treat patients!

Study Description

This is a three to four visit study, spanning approximately two-twelve weeks, in which subjects with asthma, cystic fibrosis, and healthy adult volunteers will undergo screening, baseline characterization, a non-invasive challenge test with inhaled alkaline glycine buffer, followed by repeated measurements of airway function and inflammation, and a research bronchoscopy.

Additional Information

For more information, call us at 317-274-8895 or

  • IRB Number: 1904631922
  • Research Study Identifier: TX11041
  • Principal Investigator: James Chmiel

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