GSNOR Phenotyping/GSNO Challenge in Severe Asthma
This is a three to four visit study, spanning approximately two to six weeks, in which subjects with asthma and healthy volunteers will undergo screening, baseline characterization, a research bronchoscopy, and a non-invasive challenge test with inhaled GSNO followed by repeated measurements of airway function and inflammation.
Asthma is common but some people don’t respond to traditional treatments. This could be
because some asthma patients have high levels of a protein (GSNOR) that reduces the amount
of a chemical that relaxes airway muscles (GSNO) in their body. This can lead to the airway
muscles tightening which can cause symptoms like coughing, wheezing and shortness of
breath. There may be drugs that can target this process but first we must identify which patients
have high levels of this protein. We are developing a practical method to do just that.
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