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A Randomized Phase II/III Trial of De-Intensified Radiation Therapy for Patients with Early-Stage, P16-Positive, Non-Smoking Associated Oropharyngeal Cancer

Study Overview

The purpose of this study is to compare concurrent reduced-dose radiation therapy (RT) with cisplatin or concurrent reduced-dose radiation therapy with nivolumab to the current standard of care (standard-dose RT with cisplatin).

Study Description

Participants will be randomly assigned to receive radiation plus either cisplatin or nivolumab.


  • IRB Number: 1912360365
  • Research Study Identifier: NCT03952585
  • Principal Investigator: Greg Durm, MD
  • Principal Investigator: Amy Miller

Recruitment Status

Open

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