Phosphorus Absorption in Healthy Adults and in Patients with Moderate Chronic Kidney Disease

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: healthy | chronic kidney disease
  • Age: Between 45 - 65 Years
  • Gender: Male or Female

Inclusion Criteria
Healthy: Female subjects must be post-menopausal, surgically sterile, or confirmed not pregnant by pregnancy test and not breastfeeding
Moderate (stage 3) CKD: CKD GFR categories G3a or G3b, with any level of albumunuria
Female subjects must be post-menopausal, surgically sterile, or confirmed not pregnant by pregnancy test and not breastfeeding
Subjects must be on stable doses of medications for at least 2 months prior to the study
Exclusion Criteria
Healthy: Serum phosphate, serum calcium, potassium, or sodium outside of normal ranges
High blood urea nitrogen
Evidence of CKD using GFR and albuminuria categories G1 or G2 with A2 or A3
G3a-G5 with any level of albuminuria
CKD medical diagnosis
Medical conditions including: bowel obstruction or delayed bowel emptying, active colitis, dehydration, electrolyte disorders, diabetes, uncontrolled hypertension, celiac disease, small bowel resection, or bariatric surgery
Medications including sodium phosphates, diuretics, ACE inhibitors, angiotensin receptor blockers, NSAIDS
Medications altering P metabolism taken within the last month
Other drugs or medical conditions the investigators deem will alter P absorption
Moderate (stage 3) CKD: serious underlying systemic disease if not controlled
plans to initiate dialysis within 6 months
Hypercalcemia
Hyperphosphatemia
Serum calcium, potassium, sodium, or bicarbonate/CO2 outside of normal ranges
Medications altering P metabolism taken within the last month
Medical conditions including bowel obstruction or delayed bowel emptying, active colitis, dehydration, electrolyte disorders, celiac disease, small bowel resection, or bariatric surgery
Other drugs or medical conditions the investigators deem will alter P absorption

Recruitment Status

Closed

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