Quantifying Endothelial Dysfunction and Inflammatory Changes in Low-Risk Chest Pain Patients with Associated Anxiety Identified in the ED: A Recruitment Pilot Study
P
Paul Musey, MD
Primary Investigator
Overview
SUBJECTS ARE BEING ENROLLED THROUGH THE EMERGENCY DEPARTMENT (ER) BY INVITATION ONLY
The purpose of this study is to learn about patients that present to the Emergency Department with low risk chest pain associated with anxiety or depression. We hope to study how patients’ endothelium (the cells that line blood vessels) function under different conditions.
We also hope to study how anxiety and/or depression affect markers of inflammation found in the blood.
Additionally, we hope to learn more about the obstacles that potentially prevent subjects from attending follow up appointments.
Description
In the emergency department, subjects will complete questionnaires, an audio-recorded interview, and a blood draw.
Subjects will then be asked to complete a follow-up visit at the Clinical Research Center at IU Health University Hospital. During the follow-up visit, subjects will do the following:
- Have their blood drawn
- An ultrasound with nitroglycerin
- Complete questionnaires along with a brief interview.
Participation in this study will last approximately one month and subjects will be compensated for their time.
Eligibility
You may be eligible for this study if you meet the following criteria:
-
Conditions:
all
-
Age: Between 30 Years - 100 Years
-
Gender: All
Eligibility Criteria:
• Adult ED patients (≥30yoa) presenting to the ED at IU Health Methodist
• Chief complaint of chest pain
• HEART Score of 0-3 indicating Major Adverse Cardiac Events (MACE) risk equivalent to ≤2%
• Scores ≥15 on either or both of the Generalized Anxiety Disorder 7 item scale (GAD-7) or Patient Health Questionnaire 8 item scale (PHQ-8) indicating severe anxiety and/or depression respectively.
• Able to speak and understand English
• Chief complaint of chest pain
• HEART Score of 0-3 indicating Major Adverse Cardiac Events (MACE) risk equivalent to ≤2%
• Scores ≥15 on either or both of the Generalized Anxiety Disorder 7 item scale (GAD-7) or Patient Health Questionnaire 8 item scale (PHQ-8) indicating severe anxiety and/or depression respectively.
• Able to speak and understand English
Updated on
20 Apr 2024.
Study ID: EMER-IIR-FMD, 1910739594