Help find a way to prevent COVID-19: Participate in the AZD1222 COVID-19 vaccine study

Study Overview

Enrollment for the AZD1222 vaccine study has begun. If you're interested in participating, please complete your volunteer profile (click the Register Now! button to the right), and then go here to indicate your interest.
What is the AZD1222 COVID VACCINE Study?
The AZD1222 COVID-19 VACCINE Study will research an investigational vaccine for the prevention of COVID-19, the disease caused by the new coronavirus (SARS-CoV-2). The study is looking at how well the investigational vaccine works and how safe it is.
There is currently no approved vaccine for COVID-19. The investigational vaccine is still in the testing and evaluation phase and is not licensed for use in the general public.
The study will soon volunteers who may be at risk of COVID-19. Approximately 30,000 participants from the United States will take part in this study.

Study Description

What to expect:
In this study, participants will be randomly assigned (by chance) to receive two injections of either the investigational vaccine or placebo (four weeks apart). A placebo looks like the investigational vaccine but contains no active vaccine. There is twice as much chance of receiving the investigational vaccine than of receiving the placebo.
You will be in the AZD1222 COVID-19 VACCINE Study about two years. Several tests and assessments will be performed to monitor your health. These will include:
  • Questions about your health, any medications you have taken, and how you are feeling
  • Physical examinations
  • Measurements of vital signs (blood pressure, heart rate, breathing rate, oxygen saturation, and temperature, etc.)
  • Blood tests
  • A COVID-19 test 
The study period:
The AZD1222 COVID-19 VACCINE Study has 3 parts: screening, study treatment, and follow-up. 
  1. Screening - Up to 14 days
    You will visit the study center to see if the study is right for you, learn more about it, and decide whether you want to take part.

  2. Study treatment - 4 weeks
    You will visit the study center 2 or 3 times for study assessments. You will receive 2 shots of the study injection (4 weeks apart). The study center staff will contact you by phone, 7 days after each study injection.

  3. Follow-up - About 2 years
    You will visit the study center up to 6 times for study assessments after you have received the study injections.  You will also receive regular phone calls, emails, or text messages asking if you have any symptoms of COVID-19.
Who can take part?
You may be eligible to take part if you: 
  • are 18 years of age or older
  • are in good or stable health (you may have an underlying medical condition and still take part, if your disease is stable) 
  • have an increased risk of getting COVID-19 
  • do not have a previously confirmed diagnosis of COVID-19.
Participants will be paid for their time and participation
Those who enroll in the study will be compensated for their time. The study requires several in-person and virtual visits over a two-year period.
  • Participants will be paid $100 per in-person visit and $25 per virtual visit.
  • Study visits will be at University Hospital at the Indiana University Academic Medical Center in Indianapolis, IN.
  • Parking costs will also be covered.

  • IRB Number: 2008068735
  • Research Study Identifier: TX11191
  • Principal Investigator: Cynthia Brown, MD

Recruitment Status

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Contact Us

If you need help finding a study or have any questions, please contact us at or by phone at (888) 264-0005.