Buffered vs. Unbuffered Local Anesthesia in Mandibular Molars Diagnosed with Symptomatic Irreversible Pulpitis: A Controlled, Randomized Double-blind Study
K
Kenneth Spolnik
Primary Investigator
Overview
The purpose of this study is to determine whether one type of anesthetic (numbing medicine) will work better at numbing the nerve in a tooth than using a different type of anesthetic. A second purpose is to see if the time needed to numb the nerve in a tooth is different between the two anesthetics.
Potential research subjects will be pooled from patients scheduled to receive an endodontic evaluation and/or a nonsurgical root canal therapy (NSRCT) in the Graduate Endodontic clinic at Indiana University School of Dentistry.
Eligibility
You may be eligible for this study if you meet the following criteria:
-
Conditions:
pulpitis,irreversible pulpitis
-
Age: Between 18 Years - 80 Years
-
Gender: All
Inclusion Criteria:
- Male or Female
- Between the ages of 18 and 80 years old
- Have the ability and the willingness to independently consent to treatment and study participation.
- Must have an uncomplicated medical history (ASA I and II).
- Must be experiencing signs of irreversible pulpitis (an exaggerated response to cold that lingers longer than 10 seconds) in a mandibular molar at the time of conducting the study.
Exclusion Criteria:
- Allergies to local anesthetics/sulfites (confirmed or self-reported).
- Currently pregnant
- The use of acetaminophen or short-acting NSAIDs (i.e.-Ibuprofen) within the previous 6 hours; or longer acting NSAIDs (i.e.- naproxen) within the previous 16 hours.
- Requiring nitrous oxide during treatment.
- Unhealthy injection area with other pre-existing conditions or infections
- A negative response to cold in the proposed treatment tooth.
Updated on
13 Apr 2023.
Study ID: 11447
