Buffered vs. Unbuffered Local Anesthesia in Mandibular Molars Diagnosed with Symptomatic Irreversible Pulpitis: A Controlled, Randomized Double-blind Study

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: irreversible pulpitis | pulpitis
  • Age: Between 18 - 80 Years
  • Gender: Male or Female

Inclusion Criteria:

  • Male or Female
  • Between the ages of 18 and 80 years old
  • Have the ability and the willingness to independently consent to treatment and study participation.
  • Must have an uncomplicated medical history (ASA I and II).
  • Must be experiencing signs of irreversible pulpitis (an exaggerated response to cold that lingers longer than 10 seconds) in a mandibular molar at the time of conducting the study.

 

Exclusion Criteria:

  • Allergies to local anesthetics/sulfites (confirmed or self-reported).
  • Currently pregnant
  • The use of acetaminophen or short-acting NSAIDs (i.e.-Ibuprofen) within the previous 6 hours; or longer acting NSAIDs (i.e.- naproxen) within the previous 16 hours.
  • Requiring nitrous oxide during treatment.
  • Unhealthy injection area with other pre-existing conditions or infections
  • A negative response to cold in the proposed treatment tooth. 

 

 

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If you need help finding a study or have any questions, please contact us at inhealth@iu.edu or by phone at (888) 264-0005.