A pilot phase 2 study evaluating dose de-escalation in whole brain radiation therapy with simultaneous integrated boost for patients with brain metastases

Study Overview

This trial is a pilot, Phase 2, sequential two-cohort study designed to test two de-escalated whole brain radiation therapy (WBRT) dose levels and assess their ability to maintain acceptable in-brain distant control.

Study Description

The purpose of this study is to assess whole brain radiation therapy (known as WBRT) given with simultaneous higher dose radiation (known as SIB) targeted at individual brain tumors and the effects this treatment may have on the following areas: tumor control, memory, and specific thought processes.

Additional Information

Participants will not be paid for their participation.


  • IRB Number: 1703715651 (IUSCC-0605)
  • Research Study Identifier: TX7933
  • Principal Investigator: Gordon Watson, MD

Recruitment Status

Open

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