Reduced Intensity Conditioning for Haploidentical Bone Marrow Transplantation in Patients with Symptomatic Sickle Cell Disease

J
Jodi Skiles

Primary Investigator

Overview

We're doing this study to learn if a haploidentical transplant is safe and effective to treat SCD.

Description

The purpose of this study is to learn if a new type of allogeneic transplant called a haploidentical transplant is safe and effective to treat SCD.

Eligibility

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    sickle cell disease
  • Age: Between 5 Years - 45 Years
  • Gender: All

Inclusion Criteria
Adequate physical function
Must have a first-degree related HLA-haploidentical related donor who is willing and able to donate blood marrow
Exclusion Criteria
Participants who have an HLA-matched sibling who is able and willing to donate bone marrow
Uncontrolled bacterial, viral or fungal infection in the 6 weeks before enrollment
Evidence of HIV infection or known HIV positive serology
Participants who have received a previous HCT
Participants who have participated in another clinical trial in which the patient received an investigational or off-label use of a drug or device within 3 months of enrollment
Females who are pregnant or breastfeeding
Participants with clinically significant, uncontrolled autoimmune diesease, requiring active medical management, which, in the judgment of the local Principal Investigator, indicates that the patient could not tolerate transplantation


Additional Information:
Participants will be compensated for their participation.

Updated on 09 Mar 2024. Study ID: 1705650500

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What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

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