Effects of Modern Chemotherapy Regimens on Spermatogenesis and Steroidogenesis in Adolescent and Young Adult (AYA) Survivors of Osteosarcoma
S
Sandeep Batra, MD
Primary Investigator
Overview
This research trial studies saliva, semen, and blood samples to determine effects of chemotherapy on fertility in osteosarcoma survivors. Study biospecimen samples from osteosarcoma survivors in the laboratory may help doctors learn whether chemotherapy causes fertility problems and to learn more about the long term effects.
Description
The purpose of this study is to determine whether infertility and/or biomarkers of spermatogenesis and steroidogenesis differ in male osteosarcoma survivors treated with cisplatin with or without ifosfamide compared to male controls without a history of cancer, and to evaluate whether cisplatin with or without ifosfamide for the treatment of osteosarcoma alters sperm deoxyribonucleic acid (DNA) methylation.
Eligibility
You may be eligible for this study if you meet the following criteria:
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Conditions:
osteosarcoma
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Age: Between 18 Years - 50 Years
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Gender: Male
Inclusion Criteria
Previously enrolled and randomized on AOST0331 or INT0133 (also known as CCG7921 and POG9351)
Osteosarcoma survivors without relapse or a subsequent malignancy other than skin cancer following initial treatment on AOST0331 or INT0133 (also known as CCG7921 and POG9351)
Able to speak, read and write in English or Spanish
Additional Information:Previously enrolled and randomized on AOST0331 or INT0133 (also known as CCG7921 and POG9351)
Osteosarcoma survivors without relapse or a subsequent malignancy other than skin cancer following initial treatment on AOST0331 or INT0133 (also known as CCG7921 and POG9351)
Able to speak, read and write in English or Spanish
Participants will not be paid for their participation.
Updated on
24 Apr 2024.
Study ID: 1712550596 (PHO-PRADHAN-COG-ALTE16C1)