Functional and Neurochemical Substrates of Chemotherapy-Related Cognitive Deficits

K
Karmen Yoder

Primary Investigator

Overview

What is this study about?
The purpose of this study is to understand how chemotherapy alters brain function and brain chemistry.


Description

What will happen during the study?
  • Eligible participants will be enrolled in the study that will take place over 1-3 days.  
  • The visit will take approximately 6-7 hours and could be done over 2 days. 
  • Participants will receive $100 for completion of all study procedures.

Eligibility

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    healthy, breast cancer
  • Age: Between 18 Years - 55 Years
  • Gender: Female

Inclusion Criteria
  • Able to complete and understand study questionnaires and procedures in English
  • Breast cancer survivors with a history of non-metastatic disease and chemotherapy treatment, between 6 months to five years post-chemotherapy completion
OR
  • Healthy

Exclusion Criteria
  • Any neurological or other medical disorder which may compromise subject safety or influence study outcomes (e.g., stroke, Parkinson's Disease, epilepsy, high blood pressure, diabetes, liver disease, cardiovascular disease, metastatic brain cancer, dementia)
  • Women who are pregnant, breast-feeding, or of childbearing potential and not using birth control
  • Current cigarette or marijuana smoking
  • Taking any medication in the past 30 days which could influence study outcomes (e.g. dopaminergic psychotropic medications or SNRIs)
  • Taking prescription opioid medication
  • Dependence on any drug other than caffeine or nicotine
  • Having no telephone or a reliable way in which study personnel can contact them
  • Subjects who are claustrophobic and cannot tolerate imaging procedures
  • Subjects who are contraindicated for magnetic resonance imaging (MRI) on standard IU screening forms: subjects who have metal implants, surgical devices, or other metal objects that would compromise the subject?s health during the MRI
  • Subjects who weigh > 350 lb. (upper weight limit of scanner beds)

Updated on 21 Nov 2023. Study ID: 1711139160

Interested in the study?

Select a study center that’s convenient for you, and get in touch with the study team.

Contact a study center