Dietary Nitrate and Muscle Power with Aging
The purpose of this study is to see if drinking beetroot juice (BRJ) is beneficial for aging subjects.
After you complete a screening visit, if you are determined to be eligible, your participation in the study would involve 6 separate outpatient visits at the Indiana Clinical Research Center at IU-Health University Hospital at 550 University Boulevard in Indianapolis, each 1 week apart. For each visit you will fast for 12 hours. On the first day you will drink beet juice and have your muscle function tested. Samples of your breath, blood, and muscle will also be obtained during this visit. Your muscle sample will be obtained by numbing the thigh muscle and making a small incision, and then inserting a needle into the muscle to obtain a small piece of muscle tissue. This procedure is typically painless with only a small amount of pressure being felt. This visit will take approximately 4-5 hours. After this experiment is over, you would be given a 1 week supply of the beet juice to take with you and drink daily, and you will return 1 week later to provide blood (12 hour fast required), and breath samples. This visit will take approximately 1 hour. At this point, you will be given another 1 week supply of beet juice, then return to repeat the same experiment as before where you perform the exercise test and provide blood (12 hour fast required), breath and muscle samples (about 4 hours). After a 2 week “washout” period without drinking beet juice, the above described sequence of tests will then be repeated. During the study you will also wear an activity monitor which tracks how much physical activity you are doing. In total, your participation in the study will last about 2 months.
Participants will be compensated for their participation.
- IRB Number: 1712579448
- Research Study Identifier: TX8638
- Principal Investigator: Andrew Coggan