A Phase II Study to Evaluate the Safety Pharmacodynamics and Efficacy of Entinostat in Combination with Nivolumab plus Ipilimumab in Patients with Renal Cell Carcinoma Previously Treated with Nivolumab plus Ipilimumab

Study Overview

This study is being done to test the safety of combining Entinostat with Nivolumab and Ipilimumab. It will also measure the percentage of patients whose tumor shrank after receiving Entinostat with Nivolumab and Ipilimumab.

Study Description

This study will assess the immunomodulatory activity of entinostat in patients who have progressed while receiving the immune-checkpoint inhibitors nivolumab and ipilimumab.

Additional Information

Participants will not be paid for their participation.


  • IRB Number: 1803724970 (GU17-326)
  • Research Study Identifier: TX8870
  • Principal Investigator: Roberto Pili, MD

Recruitment Status

Open

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