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A Dose Escalation Study of Intensity Modulated Total Marrow Irradiation (IMRT-TMI) with Fludarabine as a Myeloablative Conditioning Regimen for Allogeneic Hematopoietic Stem Cell Transplantation for Patients with Relapsed and Refractory Hematologic Malignancies

Study Overview

The purposes of this study are to: (1) find the most effective dose of a new type of radiation therapy called total marrow irradiation (TMI) that will be given with the conditioning chemotherapy, fludarabine, to prepare patients for allogeneic hematopoietic stem cell transplantation (Allo-HSCT); and (2) see if utilization of TMI in place of total body irradiation (TBI) will reduce side effects by giving less radiation to organs at risk.

Study Description

The purpose of this study is to find the most effective dose of a new type of radiation therapy called total marrow irradiation (TMI) that is given with a type of chemotherapy called fludarabine to prepare patients for allogeneic hematopoietic stem cell transplantation (Allo-HSCT).

Additional Information

Participants will not be paid for their participation.


  • IRB Number: 1803628152 (IUSCC-0652)
  • Research Study Identifier: TX9082
  • Principal Investigator: Naoyuki Saito, MD

Recruitment Status

Open

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