T2 Protect AD: Troriluzole Trial (T2) for Alzheimer's Disease
M
Martin Farlow, MD
Primary Investigator
Overview
T2 Protect AD is a clinical trial testing the investigational drug troriluzole in people with mild to moderate Alzheimer’s disease (AD).
The study is designed to determine whether this new drug can protect against, slow down, or potentially improve memory and thinking problems that increase as Alzheimer’s disease progresses.
Troriluzole is a drug that affects a chemical in the brain called glutamate. Problems with glutamate in the brain can affect nerve health and communication and may lead to nerve cell death. Nerve cell death leads to diseases, including Alzheimer’s.
Troriluzole may be beneficial to people with early Alzheimer’s disease by improving symptoms and/or slowing the progression of the disease.
The study is being conducted by Dr. Farlow/Indiana University. Study visits take place at Goodman Hall at the IU Health Neuroscience Center in Indianapolis. This study is sponsored by Biohaven Pharmaceuticals Inc.
Description
Participation in the study will take 48 weeks. A potential participant will first go through a screening process to see if they are eligible to take part in the clinical trial.
Screening includes:
• Memory and thinking tests
• EKGs (a look at your heart rhythms)
• MRI scans (a picture of your brain that shows changes related to Alzheimer’s disease)
Basic Eligibility Criteria
• Women and men aged 50-85 years old
• Diagnosed with mild to moderate Alzheimer’s disease
• Taking Alzheimer’s medication(s) for at least three months:
• Donepezil/Aricept® or rivastigmine/Exelon® or galantamine/Razadyne®
• With or without memantine/ Namenda®
• Living in the community (not in a residential nursing home)
• Must have a study partner who knows the participant well and can come to study visits
• Willing to participate in the T2 Study for 48 weeks
Eligibility
You may be eligible for this study if you meet the following criteria:
-
Conditions:
Alzheimer's disease,dementia,mild dementia,mild Alzheimer's disease,early Alzheimer's disease,early dementia,memory problems,memory loss,moderate Alzheimer's disease,moderate dementia,1805599086
-
Age: Between 50 Years - 85 Years
-
Gender: All
• Diagnosed with mild to moderate Alzheimer’s disease
• Taking Alzheimer’s medication(s) for at least three months:
• Donepezil/Aricept® or rivastigmine/Exelon® or galantamine/Razadyne®
• With or without memantine/ Namenda®
• Living in the community (not in a residential nursing home)
• Able to identify a study partner who has regular contact with the trial participant and can accompany the participant to clinic visits
• Willing to participate in the T2 Study for 48 weeks
COSTS
There will be no charge to you for your
participation in this study. The study
drug, study-related procedures, and study visits will be provided at no charge
to you or your insurance company.
COMPENSATION FOR PARTICIPATION
For your time and
inconvenience related to your participation in this study, you will be paid up
to a total of $675 if you complete this study.
If you do not complete the study, for any reason, you will be paid for
the study visits you do complete according to the following schedule: $75 for each
completed study visit. You will be paid
by check for each completed visit.
You will receive
complimentary parking at each clinic visit.
Updated on
20 Apr 2024.
Study ID: 1805599086