Study Overview

DID YOU KNOW?.... The germ Haemophilus ducreyi (H. ducreyi) causes a type of skin infection that has become a public health problem in developing countries, such as Africa, Asia and the tropics.
More information is needed to find out how the skin disease caused by the germs progresses over time, and how the human immune system fights the disease.
That is why researchers in the Division of Infectious Diseases at Indiana University School of Medicine are studying this germ to determine how the bacteria infects the skin, how the bacteria causes infection, and why some people get sores and others do not.

Your participation will provide researchers information that may be used to develop a vaccine to prevent this type of skin infection or lead to the development of new antibiotic treatments.

Study Description


Additional Information

Who is Eligible
  • Adults ages 21-65
  • Overall general good health
  • Must be willing to attend in-person study visits in Indianapolis daily (except for Saturdays or Sundays)
What is Involved
  • Participants will be infected on the upper arm with H. ducreyi until the infection resolves or they develop a pustule.
  • Participants will be asked to attend in-person study visits at University Hospital and the Medical Science building on the IUPUI campus in Indianapolis, IN.
  • Volunteers must be willing to be HIV tested and undergo skin biopsies.
  • The total duration of participation is 3 weeks, with follow-up phone calls 8 weeks, 12 weeks, and 6 months later.
  • Participants will be compensated for their time and will receive $50 for the screening visit, $50 for the inoculation visit, $50 for each biopsy, and $25 for each follow up visit.  Free parking or bus fare tickets will also be provided on the day of each study visit.
IF YOU ARE INTERESTED IN PARTICIPATING, please submit your information using the contact form below or call (317) 274-8473 and leave a voice mail message for Sarah. Your call will be returned.  Risks will be disclosed prior to study enrollment.

Study Title:  Experimental human infection with Haemophilus ducreyi

  • IRB Number: 1011003808
  • Research Study Identifier: TX1613
  • Principal Investigator: Stanley Spinola

Recruitment Status


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