Human Ethanol Augmented Platelet Activating Factor Production
M
Martin Plawecki, MD, PhD
Primary Investigator
Overview
The purpose of this study is to provide an explanation for the well-known finding that links alcohol with enhanced morbidity and mortality in environmental skin injuries.
Description
The main purpose of this study is to determine if combining alcohol and ultraviolet light (sun burn rays) might result in increased production of platelet activating factor (PAF), a cellular response to varying burns, as well as acute cutaneous responses as measured by skin inflammation.
Eligibility
You may be eligible for this study if you meet the following criteria:
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Conditions:
healthy,1511925931
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Age: Between 21 Years - 40 Years
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Gender: Male
Inclusion Criteria
Sunburn easily
Moderate (less than 14 drinks/week), non-dependent, physically healthy drinkers
Have venous access sufficient to allow blood sampling and alcohol infusion
Able to understand questionnaires/procedures in English
Have venous access sufficient to allow blood sampling and alcohol infusion
Able to understand questionnaires/procedures in English
Exclusion Criteria
Medications, medical conditions, or psychological symptoms that can affect safety or data validity, including but not limited to any skin related treatment or condition, allergies including those to skin numbing medications, systemic diseases with poor healing, or abnormal reactions to light.
Desire to be treated for any substance use disorder
Court-mandated order to not drink alcohol
Failure to pass alcohol or drug screen on day of study
Cannot abstain from tobacco use for 4 hour without withdrawal symptoms
Body mass index (BMI) either too low or high, preventing accurate BrAC control
Any conditions or history in the clinical judgment of the Investigators which may increase risk to the subject or invalidate study results
Desire to be treated for any substance use disorder
Court-mandated order to not drink alcohol
Failure to pass alcohol or drug screen on day of study
Cannot abstain from tobacco use for 4 hour without withdrawal symptoms
Body mass index (BMI) either too low or high, preventing accurate BrAC control
Any conditions or history in the clinical judgment of the Investigators which may increase risk to the subject or invalidate study results
Updated on
26 Apr 2024.
Study ID: 1511925931
