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Phase III Randomized Trial of Post-Radiation Chemotherapy in Patients with Newly Diagnosed Ependymoma Ages 1 to 21 years

Study Overview

This randomized phase III trial is studying maintenance chemotherapy to see how well it works compared to observation following induction chemotherapy and radiation therapy in treating young patients with newly diagnosed ependymoma.

Study Description

The purpose of this study is to determine the event-free survival (EFS) and overall survival (OS) of children with completely resected ependymoma treated with maintenance chemotherapy comprising vincristine sulfate, cisplatin, etoposide, and cyclophosphamide (VCEC) versus observation following post-operative conformal radiotherapy (cRT).

Additional Information

Participants will not be paid for their participation.


  • IRB Number: 1106005970 (PHO-COG-FALLON-ACNS0831)
  • Research Study Identifier: TX500
  • Principal Investigator: Batra Sandeep, MD

Recruitment Status

Open

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