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A Phase II Study of Cabozantinib (XL184) for Plexiform Neurofibromas in Subjects With Neurofibromatosis Type 1 in Children and Adults

Study Overview

The purpose of this Phase II Study is to determine the response rate of NFI patients with plexiform neurofibromas treated with Cabozantinib therapy using MRI scans.

Study Description

This phase II open label study will evaluate adolescents and adults with neurofibromatosis type-1 (NF1) and plexiform neurofibromas treated with cabozantinib (XL184).

Additional Information

Participants will not be paid for their participation.


  • IRB Number: 1305011412 (1305005374) (CABOZANTINIB)
  • Research Study Identifier: TX3396
  • Principal Investigator: Michael Ferguson, MD

Recruitment Status

Open

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