Investigating a Novel Modifiable Factor Affecting Renal Function After Partial Nephrectomy: Cortical Renorrhaphy

C
Chandru Sundaram, MD

Primary Investigator

Overview

Preserving kidney function during removal of a kidney tumor is becoming increasingly important as rates of chronic kidney disease increase. A novel modifiable factor (suture closure of the defect caused by tumor removal) was discovered on retrospective studies to account for nearly two-thirds of the 15% volume loss commonly seen in operated kidneys. We hypothesize that a randomized controlled surgical trial will show that omitting the suture closure both preserves renal function and will not lead to unreasonable postoperative complications.

Description

The purpose of this study is to evaluate a never before studied modifiable factor affecting renal function after partial nephrectomy: the suture closure of the renal cortex after tumor removal (renorrhaphy).

Eligibility

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    Renal Cell Carcinoma
  • Age: Between 18 Years - 100 Years
  • Gender: All

Inclusion Criteria
Presence of cT1 renal mass by diagnostic CT assessment.
Scheduled for partial nephrectomy of renal mass.
Expected survival of at least 3 months.
ECOG ? 1.
Negative serum/urine pregnancy test within 24 hours for females of child bearing age prior to surgery
Recovered from toxicity of any prior therapy to grade 1 or better
If biopsy of mass has been done, pathology must be consistent with RCC.
Exclusion Criteria
Solitary kidney
Multiple or bilateral renal masses
Hepatic or renal toxicity (GFR leeding diathesis or inability to hold anticoagulation for surgery
Participation in another investigational trial concurrently or within 30 days
Significant acute or chronic medical, neurologic, or psychiatric illness in the subject that, in the judgment of the Principal Investigator, could compromise subject safety, limit the subject's ability to complete the study, and/or compromise the objectives of the study.


Additional Information:

Updated on 20 Nov 2022. Study ID: 1403908221 (IUCRO-0459)

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