SARC024; A Blanket Protocol to Study Oral Regorafenib in Patients With Refractory Liposarcoma Osteogenic Sarcoma and Ewing/Ewing-like Sarcomas

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Osteogenic Sarcoma | Ewing/Ewing-like Sarcoma | Rhabdomyosarcoma | Liposarcoma
  • Age: Between 18 - 100 Years
  • Gender: Male or Female

Inclusion Criteria
Patients must have histologically or cytologically confirmed advanced/metastatic liposarcoma, osteogenic sarcoma, or Ewing/Ewing-like sarcoma of soft tissue or bone
At least one prior line of systemic therapy for the sarcoma diagnosis (neoadjuvant, adjuvant or metastatic disease)
Must be able to swallow and retain oral medication
Adequate organ function within 14 days of registration INR (International Normalized Ratio)
Exclusion Criteria
Prior systemic therapy with a small molecule oral kinase inhibitor
Previous assignment to treatment during this study
Concurrent, clinically significant, active malignancies within 12 months of study enrollment
Severe and/or uncontrolled concurrent medical disease that in the opinion of the investigator could cause unacceptable safety risks or compromise compliance with the protocol
Major surgery within 28 days prior to study registration or those patients who have not recovered adequately from prior surgery
Women who are pregnant or breast-feeding

Recruitment Status


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