S1400 Phase II/III Biomarker-Driven Master Protocol for Second Line Therapy of Squamous Cell Lung Cancer

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Lung Cancer
  • Age: Between 18 - 100 Years
  • Gender: Male or Female

Inclusion Criteria
Patients must have pathologically proven squamous cell non-small cell lung cancer (NSCLC) confirmed by tumor biopsy and/or fine-needle aspiration
Disease must be either advanced, incurable stage IIIB or stage IV NSCLC
Patients must have progressed after receiving exactly one front-line platinum containing metastatic chemotherapy regimen
Patients must have adequate tumor tissue available
Exclusion Criteria
Patients have a known epidermal growth factor receptor (EGFR) mutation or anaplastic lymphoma kinase (ALK) fusion
Patients whose biomarker profiling results indicate the presence of an EGFR mutation or ALK fusion
Patients have documented evidence of acute hepatitis or have an active or uncontrolled infection
Patients have a known history of human immunodeficiency virus (HIV) seropositivity
Pregnant or nursing
Patients have a history of organ transplant that requires use of immunosuppressives
Patients have a known history of tuberculosis
Patients have known HIV, hepatitis B or C positivity
Patients have Type 1 or 2 diabetes which requires insulin
Patients have active or a history of small or large intestine inflammation such as Crohn's disease or ulcerative colitis
Patients require daily supplemental oxygen

Recruitment Status

Closed

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