Targeting Polyamines using DFMO in Persons with Type 1 Diabetes: A Randomized Double-Masked Placebo-Controlled Phase I/II Study to Evaluate the Safety Tolerability and Initial Pharmacodynamics of Multiple Ascending Doses

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: type 1 diabetes
  • Age: Between 12 - 40 Years
  • Gender: Male or Female

Inclusion Criteria
Clinical diagnosis of type 1 diabetes within 2-8 months
Normal hearing
Exclusion Criteria
Presence of severe, active disease that interferes with dietary intake or requires the use of chronic medication, with exception of well-controlled hypothyroidism and mild asthma not requiring oral steroids
Diabetes other than T1D
Chronic illness known to affect glucose metabolism
Inability to swallow pills
Psychiatric impairment or current use of anti-psychotic medication
Hematologic abnormalities
Impaired renal function

Recruitment Status


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