Pilot study of the effect of weight loss on breast tissue and blood biomarkers in women at increased risk for breast cancer

T
Tarah Ballinger, MD

Primary Investigator

Overview

The purpose of this study is to see the effects that weight loss after bariatric surgery might have on certain breast cancer biomarkers and breast density.

Description

The purpose of this study is to investigate the effect of dramatic weight loss secondary to bariatric surgery on biomarkers of breast cancer tissue and blood as well as on imaging in women at elevated risk for breast cancer.

Eligibility

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    breast cancer,obesity
  • Age: Between 18 Years - 75 Years
  • Gender: Female

Inclusion Criteria
Must be at elevated risk for breast cancer
Must be willing to provide a core tissue biopsy at baseline and with repeat tissue collection after 2 weeks and 12 months post-bariatric surgery
ECOG Performance Status of 0 - 1 within 28 days of registration
Patients must be planning to undergo primary bariatric surgery (no revisions)
Exclusion Criteria
No history of any malignancy except adequately treated non-melanoma skin cancer, curatively treated in-situ cancer of the cervix, or other solid tumors curatively treated with no evidence of disease for > or = 5 years
No concurrent or planned participation in randomized trials of weight loss or exercise interventions or trials targeting insulin, IGF-1, or their receptors
Weight cannon exceed 500 lbs. at the time of imaging
Known allergy to gadolinium which us used for MRI contrast


Additional Information:
Participants will be compensated for their participation.

Updated on 20 Nov 2022. Study ID: 1511957605 (IUSCC-0556)

Interested in the study?

Select a study center that’s convenient for you, and get in touch with the study team.

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