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PHO-COG-CROOP-ADVL1312; A Phase 1/2 Study of AZD1775 (MK-1775) in Combination With Oral Irinotecan in Children Adolescents and Young Adults ...
This phase I/II trial studies the side effects and best dose of WEE1 inhibitor MK-1775 and irinotecan hydrochloride in ...
James Croop, Md, Phd
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A Phase 1/2 Study of Nivolumab in Children Adolescents and Young Adults With Recurrent or Refractory Solid Tumors as ...
The purpose of this study is to determine the side effects and best dose of nivolumab when given with or ...
James Croop, Md, Phd
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A Phase 1 Study of Selinexor (KPT-330 IND#125052) a Selective XPO1 Inhibitor in Recurrent and Refractory Pediatric Solid Tumors ...
The investigators will conduct a phase 1 trial of Selinexor in children with recurrent or refractory solid tumors, including CNS ...
James Croop, Md, Phd
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A Phase 1 Study Of Ramucirumab a Human Monoclonal Antibody Against the Vascular Endothelial Growth Factor-2 (VEGFR-2) Receptor in Children ...
The main purpose of this study is to evaluate the safety of the study drug known as ramucirumab in children ...
James Croop, Md, Phd
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A Phase 1 Multi-center Open-label Dose De-escalation Study to Evaluate the Safety and Efficacy of Talimogene Laherparepvec in Pediatric Subjects ...
This is a phase 1 study to evaluate the safety of intralesional talimogene laherparepvec administration in pediatric subjects with advanced ...
James Croop, Md, Phd
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A Phase 1 Study of ABI-009 (NAB-RAPAMYCIN) in Pediatric Patients With Recurrent or Refractory Solid Tumors Including CNS Tumors as ...
This phase I trial studies the side effects and best dose of nanoparticle albumin-bound rapamycin when given together with temozolomide ...
James Croop, Md, Phd
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A Phase 1/2 Study of Lenvatinib in Combination With Everolimus in Recurrent and Refractory Pediatric Solid Tumors Including CNS ...
In this study, you will receive the combination of lenvatinib with everolimus. The main purpose of this study is: To ...
James Croop, Md, Phd
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A Phase 1 Study of Pevonedistat (MLN4924) a Cullin Ligase Inhibitor in Combination With Temozolomide and Irinotecan in Pediatric Patients ...
This phase I trial studies the side effects and best dose of pevonedistat when giving together with irinotecan hydrochloride and ...
James Croop, Md, Phd
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A Phase 1/2 Trial of VX15/2503 in Children Adolescents or Young Adults With Recurrent or Relapsed Solid Tumors
This phase I/II trial studies the side effects and best dose of anti-SEMA4D monoclonal antibody VX15/2503 (VX15/2503 ...
James Croop, Md, Phd
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A Non-randomized Open-label Multi-center Phase I/II Study of Phosphatidylinositol-3-kinase (PI3K) Inhibitor Copanlisib in Pediatric Patients With Relapsed/Refractory Solid ...
This study is designed to investigate whether the use of copanlisib is safe, feasible and beneficial to pediatric patients with ...
James Croop, Md, Phd
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