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Found 142 will-simon trials

A listing of will-simon medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

A Phase II Trial of Cabozantinib With Patients With Refractory GCTs

N
Nabil Adra, MD
All genders
Phase 2
Interventional
The purpose of the CTO-IUSCCC-0752 study is to investigate the use of Cabozantinib forwith incurable, refractory germ cell tumors. Patients will be treated until evidencedisease progression, non-compliance with study protocol, unacceptable major toxicity, atubject's own request for withdrawal, or if the study closes for any reason.
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Evaluating a 3D Printed Oral Stent Device with Suction for Oral Cancer RT

M
Mark Langer, MD
18-100 years
All genders
A foam bite is the standard device used to hold the tongue in place during radiation treatment of cancers of the tongue. There is no device currently available to fix the tongue in place and remove oral secretions (i.e. saliva) through suction tubing attached to the stent. We wish to see …
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Exercise in Metastatic Breast Cancer: EMBody

T
Tarah Ballinger, MD
18 years and older
All genders
Phase 2
Interventional
The purpose of this study is to study exercise in a novel population with indolent MBC (nogression on current therapy in prior 12 months and not receiving cytotoxic chemotherapy). The study team hypothesizes that delivering virtual, supervised, progressive intensitybic and resistance training exercise for 16 weeks in this population will …
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Pilot ex-vivo investigation of an experimental beta probe for assessment and guidance of prostate cancer resection

C
Clinton Bahler, MD
18-100 years
All genders
68Ga-PSMA is a radiopharmaceutical used with PET imaging for the detection of prostate cancer under a compassionate IND in patients who have presented with biochemical failure. In this study, the use of 68Ga-PSMA-11 will be extended to newly diagnosed patients with high risk prostate cancer. Patients enrolled to this study …
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A Phase 2 Study of the MEK Inhibitor Trametinib in Children With Relapsed or Refractory Juvenile Myelomonocytic Leukemia

S
Sandeep Batra, MD
21 years and younger
All genders
This phase II trial studies how well trametinib works in treating patients with juvenile myelomonocytic leukemia that has come back or does not respond to treatment.
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Tomosynthesis Mammographic Imaging Screening Trial (TMIST)

S
Steven Westphal, MD
45-74 years
Female
This randomized phase III trial studies digital tomosynthesis mammography and digital mammography in screening patients for breast cancer.
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A Phase 1a/1b Study of LY3537982 in Patients with KRAS G12C-Mutant Advanced Solid Tumors

G
Greg Durm, MD
18-100 years
All genders
Phase 1/2
To determine the recommended Phase 2 dose (RP2D) of LY3537982 monotherapy in patients with KRAS G12C-mutant advanced solid tumors
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Avelumab or Hydroxychloroquine With or Without Palbociclib to Eliminate Dormant Breast Cancer (PALAVY)

K
Kathy Miller, MD
18 years and older
All genders
Phase 2
Interventional
This clinical trial will assess the safety and early efficacy of Hydroxychloroquine or Avelumab, with or without Palbociclib, in early-stage ER+ breast cancer patients who areund to harbor disseminated tumor cells (DTCs) in the bone marrow after definitive surgeryd standard adjuvant therapy.
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Key Adverse Events Following Childhood Cancer

S
Sandeep Batra, MD
21 years and younger
All genders
The goal of this study is to identify subjects who are more likely to develop a late-occurring complication(s) after undergoing treatment for childhood cancer.
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Neuropsychological Social Emotional and Behavioral Outcomes in Children with Cancer

S
Sandeep Batra, MD
1-21 years
All genders
This research trial studies neuropsychological (learning, remembering or thinking) and behavioral testing in younger patients with cancer. Collecting information over time from a series of tests may help doctors develop effective tests to measure neuropsychological and behavioral function of patients with cancer.
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