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Found 86 Neoplasms trials

A listing of Neoplasms medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Tiragolumab and Atezolizumab for the Treatment of Relapsed or Refractory SMARCB1 or SMARCA4 Deficient Tumors

M
Melissa Bear, MD
12 years and older
All genders
Phase 1/2
Interventional
This phase I/II trial studies how well tiragolumab and atezolizumab works when given tohildren and adults with SMARCB1 or SMARCA4 deficient tumors that that has either come back (relapsed) or does not respond to therapy (refractory). SMARCB1 or SMARCA4 deficiency meanshat tumor cells are missing the SMARCB1 and SMARCA4 genes, …
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A Phase 1/2 Trial of VX15/2503 in Children Adolescents or Young Adults With Recurrent or Relapsed Solid Tumors

J
James Croop, MD, PhD
1-30 years
All genders
This phase I/II trial studies the side effects and best dose of anti-SEMA4D monoclonal antibody VX15/2503 (VX15/2503) and to see how well it works in treating younger patients with solid tumors that have come back after treatment, or do not respond to treatment.
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Pilot ex-vivo investigation of an experimental beta probe for assessment and guidance of prostate cancer resection

C
Clinton Bahler, MD
18-100 years
All genders
68Ga-PSMA is a radiopharmaceutical used with PET imaging for the detection of prostate cancer under a compassionate IND in patients who have presented with biochemical failure. In this study, the use of 68Ga-PSMA-11 will be extended to newly diagnosed patients with high risk prostate cancer. Patients enrolled to this study …
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Biodistribution and dosimetry of the investigational PET agent 68Ga-P16-093 in prostate cancer patients with biochemical recurrence undergoing clinical 68Ga-PSMA-11 PET/CT

M
Mark Green
18-100 years
Male
Whole body biodistribution and dosimetry with preliminary comparison to PSMA-11 in prostate cancer patients with biochemical recurrence
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DORA Trial: Phase III Trial of Docetaxel vs. Docetaxel and Radium-223 for Metastatic Castration-Resistant Prostate Cancer (mCRPC)

R
Roberto Pili, MD
18-100 years
Male
The purpose of this study is to compare any good and bad effects of using radium-223 along with docetaxel chemotherapy treatment versus using docetaxel alone.
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A Phase 1/2 Study of Nivolumab in Children Adolescents and Young Adults With Recurrent or Refractory Solid Tumors as a Single Agent and in Combination With Ipilimumab

J
James Croop, MD, PhD
1-30 years
All genders
The purpose of this study is to determine the side effects and best dose of nivolumab when given with or without ipilimumab to see how well they work in treating younger patients with solid tumors or sarcomas that have come back (recurrent) or do not respond to treatment (refractory).
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A COG Soft Tissue Sarcoma Biology and Banking Protocol

S
Sandeep Batra, MD
50-100 years
All genders
The purpose of this study is to better diagnose certain types of cancer.
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RADY-GU-SAYKIN-TLC; Older breast cancer patients: Risk for cognitive decline

A
Andrew Saykin, PsyD
60-100 years
Female
We are looking for healthy women (who have never had cancer) to participate in a study of at Indiana University School of Medicine. We are working to better understand cognitive changes after breast cancer treatment.
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Tissue Procurement Protocol for the Developmental Therapeutics Clinic National Cancer Institute (NCI)

A
Anna Maria Storniolo, MD
110 years and younger
All genders
The purpose of this study is to obtain samples for research purposes from tests performed for clinical indications or research indications on other research protocols, and to obtain samples for research purposes from non-surgical procedures, performed for the sole purpose of obtaining samples for this protocol.
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Long-Term Adverse Health Outcomes in Survivors of Germ Cell Tumors Treated with High Dose Chemotherapy

M
Mohammad Abu Zaid, MD
18-65 years
Male
Observational
The purpose of this study is to compare men who were treated for testicular cancer and received high dose cisplatin-based chemotherapy and peripheral blood stem cell transplant to those who received conventional doses of cisplatin-based chemotherapy for treatment of the same disease and men who have never been diagnosed with …
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