High Impact Lifestyle Intervention in Adults with High Blood Pressure (

D
Daniel Clark

Primary Investigator

Overview

The goal of Phase 1 is to assess the flow of the multistage inclusion screen and multifaceted intervention to support an anticipated NIA resubmission of a randomized clinical trial (RCT) testing the feasibility and initial efficacy of a high intensity lifestyle intervention (HILI) to improve or maintain cognition and ADRD biomarkers in African-American adults with hypertension and a family history of memory loss and thus at high risk for dementia. 

Description

This phase serves to pilot a portion of the full study design for which NIA funding has been sought. For up to 18 subjects, the pilot includes modified recruitment, abbreviated study procedures, and only 1 interventional arm (out of the intended 4 arms) of the intended full study design. The goal of Phase 1 is to assess the flow of the multistage inclusion screen and multifaceted intervention to support an anticipated NIA resubmission of a randomized clinical trial (RCT) testing the feasibility and initial efficacy of a high impact lifestyle intervention (HILI) to improve or maintain cognition and ADRD biomarkers in African-American adults with hypertension and a family history of memory loss and thus at high risk for dementia. Phase 2 will be added to the protocol and submitted to IRB in the event funding is received.

Eligibility

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    memory loss, dementia
  • Age: Between 18 Years - 100 Years
  • Gender: All

Inclusion Criteria:
  • 1.     English speaking
    2.     U.S. born
    3.     African-American
    4.     40-70 years
    5.     Ability to see and read street signs (self report)
Exclusion Criteria:
  • 1.     resistant HTN identified using the TRIUMPH definition (BP of ≥140/90 while on 4+ HTN medications or 3+ and on thiazide diuretic)
    2.     diagnosis of dementia or Alzheimer disease or mild cognitive impairment; Parkinson disease; brain tumor/infection/surgery; psychosis, schizophrenia, or bipolar disorder
    1. prescription of donepezil,vastigmine, galantamine, or memantine, past or present
    2. unable tohe Exercise Assessment and Screening for You (EASY), or receivevider clearance for exercise
    3. alcohol consumption ≥ 8 drinks perweek for women, or ≥15 drinks per week for men
    4. changing/unstable residence tove food deliveries

Updated on 02 May 2024. Study ID: 2006147911, NTM-IIR-HILI
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