Frontal-Striatal Reward Circuit Neuromodulation and Alcohol Self-Administration
M
Michael Francis, MD
Primary Investigator
Overview
This study investigates the relationship between repetitive transcranial magnetic stimulation (rTMS) and alcohol-related behavior. The purpose of this study is to determine if repetitive transcranial magnetic stimulation (rTMS) affects subjective feelings and alcohol drinking behavior, in both lab based experiments and in normal life.
Description
Primary
Objective
The primary objective of this pilot study is to determine the effect size of the
relationship between mPFC LF rTMS and a change in the time required to
self-administer at least a binge-level alcohol exposure of 80 mg/dL. We
hypothesize that, compared to sham stimulation, mPFC LF rTMS will slow the time
to a breath alcohol concentration (BrAC) of 80 mg/dL.
Eligibility
You may be eligible for this study if you meet the following criteria:
-
Conditions:
alchoholism
-
Age: Between 21 Years - 35 Years
-
Gender: All
Inclusion Criteria:
- 1. Overtly healthy men and women aged 21 – 352. Able to give informed consent3. Able to understand/complete questionnaires and procedures in English4. Willing and able to adhere to the study schedule5. At least 2 binge drinking events (at least 4 or 5 drinks on a drinking day for women and men respectively over the last 5 weeks, unless determined by study physicians that drinking history meets study objectives6. Have venous access sufficient to allow blood sampling
Exclusion Criteria:
- 1. Pregnant or breast-feeding2. Desire to be treated for any substance use disorder or court ordered to not drink alcohol3. Medical disorders or other conditions, such as lifetime history of a seizure, including history of ECT but excluding febrile seizures and those induced by substance withdrawal, that may influence study outcome or subject safety4. First degree relative with idiopathic epilepsy or other seizure disorder5. DSM 5 Disorders (non-AUD) or current/history of neurological disease of cerebral origin, or head injury with > 20 min loss of consciousness, if determined by the study physicians to affect subject safety or data integrity6. Positive urine drug screen for amphetamines/ methamphetamines, barbiturates, benzodiazepines, cocaine, opiates, or phencyclidine if determined by the study physicians to adversely affect subject safety or data integrity7. Medications (past 30 days) that could influence subject data/subject safety (e.g. antidepressants, antipsychotics, benzodiazepines, etc.) as determined by study physicians8. Positive BrAC reading at beginning of any study session9. Actively suicidal (for example, any suicide attempts within the past 3 months or any current suicidal intent, including a plan) or are at serious suicidal risk, by clinical judgment of the study physicians
Updated on
03 May 2024.
Study ID: 11511, PSYC-IIR-RTMSARC
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