PROJECT SICKLE CURE
J
Jodi Skiles
Primary Investigator
Enrolling By Invitation
100 years and younger
All
Phase
N/A
3 participants needed
1 Location
Overview
We want to learn more about the long-term effects of Hematopoietic Stem Cell Transplantation (HSCT) on the brain and blood vessels of patients with sickle cell disease. We want to understand: how the brain looks on scans, how it functions and what brain complications develop with BMT for sickle cell disease. We also want to learn more about quality of life before and after BMT, and how you experience pain.
Description
The researchers will ask participants some health related quality of life (HRQoL) questions and have some neurocognitive testing performed at 10 study visits over 3 years. Participants can choose to participate in optional studies to collect blood samples and store those blood samples for future research. Siblings can also choose to participate by providing a single blood sample.
Eligibility
You may be eligible for this study if you meet the following criteria:
-
Conditions:
Sickle cell
-
Age: - 100 Years
-
Gender: All
Inclusion Criteria:
- HSCT recipients: Patients must be scheduled to undergo an HSCT for SCD at a STAR center. Patients will be eligible regardless of age, donor type, hematopoietic stem cell source, number of transplants, conditioning regimen, or GVHD prophylaxis. To be eligible for the biorepository, they must weigh ≥10 kg.
- Related donors: To be eligible for the biorepository, all related donors must weigh ≥10 kg.
Exclusion Criteria:
Updated on
15 May 2024.
Study ID: 14748, PHO-HCA-SICKLE-CURE
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