Posterior Default Mode Network Modulation in Heavy Drinkers Effects on Risky Behavioral Phenotypes and Brain Circuitry
M
Martin Plawecki, MD, PhD
Primary Investigator
Overview
This research study will examine the relationship between theta burst stimulation (TBS), which is a type of repetitive transcranial magnetic stimulation (rTMS) and alcohol-related behavior. Repetitive transcranial magnetic stimulation (rTMS) is a brain stimulation technique that uses a magnet to temporarily change brain function.
Description
The TBS will be combined with magnetic resonance imaging (MRI) while participants are doing different things (lying at rest, tasting alcohol and non-alcohol related drinks, and performing memory and thinking tasks; about 75-90 minutes total). TBS is a technique that uses a magnetic coil placed over the scalp to temporarily change brain function for a short period of time. Results from this study may help us better understand whether TBS might change brain communication and ultimately alcohol drinking. Participants will complete a screening visit, 3 TBS and functional magnetic resonance imaging (fMRI) sessions over approximately 3 weeks, and a phone follow-up interview 2 weeks after the third experimental session. Participants will be enrolled in this study for a total of about 4-8 weeks.
Eligibility
You may be eligible for this study if you meet the following criteria:
-
Conditions:
Alcoholism
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Age: Between 21 Years - 40 Years
-
Gender: All
Inclusion Criteria:
- Overtly physically healthy men and women aged 21 – 40
- Alcohol Cue Reactivity Screening Positive, defined as an increase of 3 “strength of craving” (adapted from the Alcohol Craving Questionnaire62) Visual Analogue Scale Units in response to exposure to a preferred beverage compared to water or significant baseline craving (Penn Alcohol Craving Scale ≥ 14)
- The Alcohol Cue Reactivity Screening Positive approach has been adopted by the NIAAA Human Laboratory Paradigm Protocols for which IU was an original contributing site62.
- At least 7 or 14 drinks per week average over the last month or more than 3 versus 4 drinks on an occasion for women and men respectively, or drinking patterns and/or behaviors that the PI determines are consistent with the objectives of the study.
- Right-handed
Exclusion Criteria:
- MRI Contraindications
- Pregnant or breast-feeding women
- Desire for AUD treatment or court ordered to not drink alcohol
- Medical disorders, such as seizure disorder or other conditions that may influence study outcome or subject safety as determined by the PIs
- Positive urine drug screen for amphetamines/ methamphetamines, barbiturates, benzodiazepines, cocaine, opiates, or phencyclidine and evidence of intoxication
- Medications or dosage changes (past 30 days) that could influence subject data/subject safety as determined by PIs
- Current/history of neurological disease of cerebral origin, head injury with > 20 min loss of consciousness, or medical treatment impacting MRI data.
- Positive BrAC reading precluding visit completion
- Actively suicidal (for example, any suicide attempts within the past year or any current suicidal intent, including a plan) or are at serious suicidal risk, by clinical evaluation by the PIs
- Left-handed or ambidextrous
- First degree family member with seizure disorder
- Inability to understand and comply with study instructions in English
Updated on
03 May 2024.
Study ID: 14019, PSYC-IIR-PDMN
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