Influence of the vaginal microbiome on cervical cell metabolism during chlamydial infection

S
Stephen Jordan

Primary Investigator

Overview

The purpose of this study is to understand if specific vaginal microbes (part of the microbiome), and their metabolites (that is, their byproducts) in women who have Bacterial Vaginosis (BV) and in women who do not have BV increase the risk for being infected with chlamydia. Information that we learn from this study may help develop future treatments and prevent chlamydia reinfections. To do this, this research study will characterize the metabolome (the metabolome is the collection of small molecules or compounds that are present in the specimens that we will collect) and active metabolic pathways in both the vagina and cervix and the associated microbiome in women with and without BV that do or do not have chlamydia.

Description

Participants will be asked questions about their health, medication use, and sexual history. Participants will have tests done for HIV, syphilis, and chlamydia. Researchers will collect samples in similar ways to a well women's pelvic exam.

Eligibility

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    chlamydia
  • Age: Between 18 Years - 35 Years
  • Gender: Female

Inclusion Criteria:
  • Women aged 18-35 returning to BFC for CT treatment due to either a positive CT NAAT test or being identified as a contact to chlamydia.
  • Women who have no known recent exposure to STIs (low risk).  
Exclusion Criteria:
  • Use of systemic anti-chlamydial antibiotics within the last 30 days
  • Diagnoses of HIV, gonorrhea, or syphilis or no prior testing within the last 30 days
  • Current menstruation
  • Current pregnancy
  • Prior hysterectomy
  • Douching within the last 30 days
  • Acute intoxication or psychiatric illness
  • Trans-gender 
  • Prior enrollment in this study

Updated on 03 May 2024. Study ID: 15593, INFD-IIR-15593
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