Comparison of Transcriptomics Before and After PAP Therapy in Obese Children with OSA.
A
Anuja Bandyopadhyay
Primary Investigator
Overview
There is a critical need to identify
differential transcriptomic expression of nasal epithelial tissue in OSA as
these can serve as diagnostic and therapeutic targets. By
identifying the difference in transcriptomic profiling in obese patients after
effective OSA treatment, we can possibly discover new diagnostic and
therapeutic targets.
Description
- To compare nasal epithelial transcriptome of obese childrenwith excessive daytime sleepiness, with and without OSA. The primaryhypothesis is that nasal epithelial tissue transcriptome of patients with OSA willdiffer from those without OSA.
- To compare nasal epithelial transcriptome of obese childrenwith excessive daytime sleepiness, before and after effective treatment ofA. The primary hypothesis is that nasal epithelial tissue transcriptome of patients with PAP treatedA will exhibit downregulation of transcriptomic signatures.
Eligibility
You may be eligible for this study if you meet the following criteria:
-
Conditions:
obstructive sleep apnea
-
Age: Between 7 Years - 18 Years
-
Gender: All
Inclusion Criteria:
- We will include all children who will cooperate with nasal tissue collection procedure (7-18 years). All patients who are obese (BMI>95th percentile) and have excessive daytime sleepiness (Epworth sleepiness score>10) will be eligible to participate.
Exclusion Criteria:
- craniofacial anomalies, including trisomy 21, neuromuscular disorder, congenital cyanotic heart disease which can independently be associated with OSA.
Updated on
03 May 2024.
Study ID: 15588, PPUL-IIR-CTAP
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